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A nocturnal tornado is causing havoc in the US, ripping through an Amazon Warehouse in Illinois and causing buildings to collapse across multiple states.

It's feared many people are 'trapped' amid rubble following the tornado's path of destruction.

Southern Illinois Fire Incidents posted an update stating seven rescue stations had rushed to a "structure collapse" at an Amazon warehouse on Gateway Commerce Drive.

It's feared up to 150 people may be trapped inside after part of the roof collapsed on Friday night, however, this is yet to be confirmed by emergency services.

It comes after the tornado struck a nursing home in Arkansas earlier on in the evening, with reports that people have died.

Two people were killed and five others hurt, according to ABC's KAIT news, at Monette Manor nursing home.

Around 20 people were trapped at the facility, which has 90 beds, after the freak weather moved through the Mississippi County area.

Photos from the scene show debris covering the car park and major damage to the building.

Tornado and severe weather warnings remain in effect, after reports that the storm has hit Illinois and Missouri.

The states under major threat include Arkansas, Tennessee, Kentucky, and Indiana, after damaging winds on Friday night move from the Rockies to the East Coast, writes ABC.

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