At least four people have died and two others are seriously injured after a horrific car crash in the United States saw the vehicle split in half.

All six people were travelling in the same car when the driver lost control and smashed into a tree at around 2:30pm on Saturday in the town of Hickory Hills, Illinois.

One of those dead is a 14-year-old girl, according to an eyewitness.

Joanna Proszek, who saw the horror collision, told ABC News' Chicago affiliate WLS: "I have never seen anything like it."

She went on: "I saw two bodies – one was behind the vehicle that was ripped apart, one was in between, and then the passenger was OK."

Joanna, who lives close to the scene of the crash, heard a sickening sound of splitting metal and ran out of her house to help.

"It was bad, tragic. I think they just, like, started flying because there is a hill," she said.

"So I am thinking they just revved up the engine and they just flew into the tree."

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None of the victims have been publicly identified as of Sunday, but WLS reports that two people were pronounced dead at the scene while another two died after being taken to hospital.

Authorities say they are investigating whether the vehicle was speeding just before the fatal crash.

Pictures from the scene show the back half of a blue-grey Mercedes SUV, with the rest of the smashed vehicle nearby.

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The airbags deployed on impact.

As of Sunday, the condition of the two surviving occupants of the crash has not been released.

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