U.S. deaths from the coronavirus pandemic topped 1,000 in another grim milestone for a global outbreak that is taking lives and wreaking havoc on economies and the established routines of ordinary life.

In a recognition of the scale of the threat, the U.S. Senate late Wednesday passed an unparalleled $2.2 trillion economic rescue package steering aid to businesses, workers and health care systems.

The unanimous vote came despite misgivings on both sides about whether it goes too far or not far enough and capped days of difficult negotiations as Washington confronted a national challenge unlike it has ever faced. The 880-page measure is the largest economic relief bill in U.S. history.

Worldwide, the death toll climbed past 21,000, according to a running count kept by Johns Hopkins University, and the U.S. had 1,050 deaths and nearly 70,000 infections.

Spain’s death toll has risen past 3,400, eclipsing that of China, where the virus was first detected in December, and is now second only to that of Italy, which has 7,500. Lidia Perera, a nurse at Madrid’s 1,000-bed Hospital de la Paz, said more workers were desperately needed. “We are collapsing,” Perera said.

The Spanish parliament voted to allow the government to extend strict stay-at-home rules and business closings until April 11.

Such measures are becoming increasingly common in the U.S., where New York is the epicenter of the domestic outbreak, accounting for more than 30,000 cases and close to 300 deaths, most of them in New York City.

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